Recent Developments in Trifluoromethylation or Difluoroalkylation by Use of Difluorinated Phosphonium Salts

Recent advances in trifluoromethylation or difluoroalkylation reactions by use of difluorinated phosphonium salts are summarized. In the presence of base, water, photocatalyst, fluoride or under the heating conditions, the difluorinated phosphonium salts can produce difluorocarbene, the CF 2 H radical or the trifluoromethyl anion, which are major intermediates for the difluoroalkylation or trifluoromethylation reaction and give moderate to excellent yields of the desired products in most cases. magnified image