Structural analyses reveal that the Rycal drug ARM210 binds to the RyR2-R2474S mutation, reverting its primed state toward the closed state and providing a mechanistic basis for its therapeutic action in catecholaminergic polymorphic ventricular tachycardia (CPVT).
leak. The Rycal drug ARM210 binds to RyR2-R2474S, reverting the primed state toward the closed state. Together, these studies provide a mechanism for CPVT and for the therapeutic actions of ARM210.
Miotto et al. (Wed,) studied this question.
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