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October 7, 2022Journal of Medicinal ChemistryOpen Access

Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity

Ross J. Collins Hyun-Ah Lee D. Heulyn Jones Jonathan M. Elkins Jason A. Gillespie Carys Thomas Alex G. Baldwin Kimberley Jones Loren Waters Marie Paine John Atack Simon E. Ward Olivera Grubisha David Foley

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pharmacological tools for the study of LIMK function in cell biology.

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Collins et al. (2022) studied this question.

synapsesocial.com/papers/6a03f66dcdf9ec677a893524 https://doi.org/10.1021/acs.jmedchem.2c00751

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulatorsReview · 2011 · 118 citations
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5Immunohistochemical Investigation of the Correlation between LIM Kinase 1 Expression and Development and Progression of Human Ovarian Carcinomacohort · 2012 · 12 citations

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