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BACKGROUND: G tRNA modification in hepatocellular carcinoma (HCC) remain poorly understood. METHODS: G tRNA modification, tRNA expression and mRNA translation efficiency. RESULTS: G-related codons. Furthermore, in vivo studies with Mettl1 knockin and conditional knockout mice reveal the essential physiological function of Mettl1 in hepatocarcinogenesis using hydrodynamics transfection HCC model. CONCLUSIONS: Our work reveals new insights into the role of the misregulated tRNA modifications in liver cancer and provides molecular basis for HCC diagnosis and treatment.
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Chen et al. (2021) studied this question.
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