What question did this study set out to answer?

To summarize existing evidence regarding how continuous and intermittent hypoxia influence neurotransmitter levels and the rate-limiting enzymes required for their synthesis in the nervous system.

January 27, 2011AJP Cell PhysiologyOpen Access

Hypoxia. 3. Hypoxia and neurotransmitter synthesis

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Authors

GKGanesh KumarKarnataka Veterinary Animal and Fisheries Sciences University

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Implication

Review reveals how oxygen deprivation alters neurotransmitter-synthesizing enzymes in neural circuits, indicating distinct impacts from sustained and intermittent exposures.

Key Points

To summarize existing evidence regarding how continuous and intermittent hypoxia influence neurotransmitter levels and the rate-limiting enzymes required for their synthesis in the nervous system.
Reviewed neurobiological literature contrasting continuous hypoxia, characteristic of high-altitude exposure, with intermittent hypoxia, typical of sleep-disordered breathing and recurrent apneas.
Evaluated central and peripheral mechanisms governing oxygen-dependent rate-limiting enzymes involved in neurotransmitter and neuromodulator biosynthesis.
Key rate-limiting enzymes governing neurotransmitter synthesis require molecular oxygen, rendering chemical signaling pathways vulnerable to disrupted oxygen homeostasis.
Continuous and intermittent hypoxia elicit distinct molecular alterations in enzyme activity, driving differential changes in transmitter levels across central neurons and peripheral neuroendocrine cells.

Cite This Study

Ganesh Kumar (2011) studied this question.

synapsesocial.com/papers/6a03fe544a5db22ff28944f1 https://doi.org/10.1152/ajpcell.00019.2011

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Implication

Review reveals how oxygen deprivation alters neurotransmitter-synthesizing enzymes in neural circuits, indicating distinct impacts from sustained and intermittent exposures.

Hypoxia. 3. Hypoxia and neurotransmitter synthesis

Discussion

Member takes

Implication

Key Points

Cite This Study

Hypoxia. 3. Hypoxia and neurotransmitter synthesis

Discussion

Member takes

Implication

Key Points

Cite This Study

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