Demonstrates neutrophil involvement in endothelial senescence in Behçet's Disease, indicating a potential target for therapy.
OBJECTIVE: PMN dysregulation on endothelial cells in Behçet's disease (BD), a chronic systemic vasculitis characterized by polymorphonuclear neutrophil (PMN) activation and endothelial dysfunction. METHODS: PMN-derived NETs were assessed. RESULTS: PMN-derived NETs contained more Histone 3.1 (H3.1). H3.1 induced senescence, SASP and PMN chemotaxis in VECs via TLR4 signaling, which was attenuated by senolytics. CONCLUSION: PMN in BD patients promote senescence and SASP in VECs through secreting H3.1-enriched NETs, which recruit PMN and collectively contribute to vasculitis in BD.
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Wang et al. (2026) studied this question.
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