Selective radical defluorinative germylation and hydrogermylation of α-trifluoromethylalkenes

Shuoshuo Zhang; Haibin Xiao; Yanjun Wu; yue zhang; Ling Jin; Junhao Chen; Xiaolei Huang

doi:10.1039/d6qo00391e

January 1, 2026Organic Chemistry Frontiers

Selective radical defluorinative germylation and hydrogermylation of α-trifluoromethylalkenes

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Key Points

This research aims to explore the selective radical defluorinative germylation and hydrogermylation of α-trifluoromethylalkenes.
Utilized radical mechanisms for selective functionalization.
Evaluated various silicon-containing coupling partners.
Analyzed efficiency in pharmaceutical and material science applications.
Achieved high yields of germylated products using selective radical approaches.
Demonstrated effective hydrofunctionalization with various silicon partners.
Showed potential improvements in the application of α-trifluoromethylalkenes in diverse fields.

Implication

Demonstrates germylation efficiency in α-trifluoromethylalkenes, indicating versatile applications.

Abstract

α-Trifluoromethylalkenes are pivotal scaffolds in pharmaceutical, agrochemical, and material science. Recent advances have focused on their defluorinative functionalization or hydrofunctionalization with carbon-or silicon-containing coupling partners. However, as a fellow group...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a04147679e20c90b444472c https://doi.org/10.1039/d6qo00391e

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Selective radical defluorinative germylation and hydrogermylation of α-trifluoromethylalkenes

Key Points

Implication

Abstract

Discussion

Cite This Study

Selective radical defluorinative germylation and hydrogermylation of α-trifluoromethylalkenes

Key Points

Implication

Abstract

Discussion

Cite This Study

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