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May 13, 2026Clinical Nuclear Medicine

68Ga-FAPI-04 PET/CT: A “New Kid on the Block” for Evaluation of Stewart-Treves Syndrome

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Why the study?

Does 68Ga-FAPI-04 PET/CT improve the detection of Stewart-Treves syndrome compared to 18F-FDG PET/CT in a patient with chronic lymphedema?

Population

A 40-year-old woman with increasing lymphedema after treatment for triple-negative left breast cancer

Comparison

18F-FDG PET/CT vs 68Ga-FAPI-04 PET/CT

Design

Case report

Key result

68Ga-FAPI-04 PET/CT demonstrated higher avidity for subcutaneous deposits of Stewart-Treves syndrome compared to 18F-FDG PET/CT, potentially aiding in early diagnosis.

Authors

KPKavita PatilGMGaurav MalhotraSRShilpa Rao

Discussion

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Overview

FAPI PET/CT may aid STS detection in chronic lymphedema; leaves open prospective validation before clinical adoption.

Key Points

  • To assess the effectiveness of 68Ga-FAPI-04 PET/CT compared to 18F-FDG PET/CT in diagnosing Stewart-Treves syndrome.
  • Evaluation of a patient with a history of breast cancer and chronic lymphedema using two imaging techniques: 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT.
  • Analysis of imaging results to determine the avidity of FAPI against FDG in diagnosing Stewart-Treves syndrome.
  • 68Ga-FAPI-04 PET/CT showed greater avidity for detecting subcutaneous deposits compared to 18F-FDG PET/CT in the patient.
  • Diagnosis of Stewart-Treves syndrome was made based on the findings from the 68Ga-FAPI-04 PET/CT scan, suggesting improved diagnostic capability.

Study Design

Type

Case Report (n=1)

Structured PICO

Does 68Ga-FAPI-04 PET/CT improve the detection of Stewart-Treves syndrome compared to 18F-FDG PET/CT in a patient with chronic lymphedema?

P
Population
A 40-year-old woman with a history of modified radical mastectomy and chemoradiotherapy for triple-negative left breast cancer, presenting with increasing lymphedema of the proximal left upper limb of 2 years' duration (n=1).
I
Intervention
68Ga-FAPI-04 PET/CT
C
Comparator
18F-FDG PET/CT
O
Outcome
Detection and avidity of subcutaneous depositssurrogate

68Ga-FAPI-04 PET/CT may offer better performance than 18F-FDG PET/CT for the early diagnosis of Stewart-Treves syndrome in breast cancer patients with chronic lymphedema.

Cite This Study

Patil et al. (2026) conducted a case report in Stewart-Treves syndrome (n=1). 68Ga-FAPI-04 PET/CT vs. 18F-FDG PET/CT was evaluated on Tracer avidity of subcutaneous deposits. 68Ga-FAPI-04 PET/CT demonstrated higher avidity for subcutaneous deposits of Stewart-Treves syndrome compared to 18F-FDG PET/CT, potentially aiding in early diagnosis.

synapsesocial.com/papers/6a0414cc79e20c90b4444b2bhttps://doi.org/10.1097/rlu.0000000000006512
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