Demonstrates the role of MYC overexpression in blocking myeloid differentiation in AML, suggesting a critical pathology element.
MYC overexpression is a crucial element of acute myeloid leukaemia (AML) physiopathology. By advanced cellular modelling and molecular analysis, Stokes and colleagues showed that MYC overexpression induces a myeloid block. Sustained expression of this oncogene is required and sufficient to maintain the block, a feature shared by multiple AML subtypes.
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Alessandro Donada (2026) studied this question.
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