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Demonstrates site-specific fluorescence switching in DNA origami, indicating dynamic programmability.
reduction of gold ions, achieving site-specific metallization. We then incorporate a fluorescent Cy3 dye into the metallized origami template to show the distance-dependent fluorescence quenching via energy transfer. As a proof of concept, we also demonstrate the dynamic programmability of the hybrid system to remove the fluorophore by using a strand displacement reaction, resulting in complete fluorescence recovery.
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Saji et al. (2026) studied this question.
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