Reveals enhanced antibody repertoire profiling using DIA-PTCR, indicating improved detection capabilities.
region was found to be sufficient to cover the total Fab distribution. This gas-phase fractionation, when also combined with reduced noise filtering, increased the number of clones detected within a single run from 1043 to 2063 (+100%). Importantly, quantitative data on antibody abundances could be retained as required for repertoire profiling. We conclude that DIA-PTCR is beneficial for LC-MS-based antibody repertoire profiling.
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Leuvenink et al. (2026) studied this question.
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