This review aims to summarize recent developments (2020–2025) in the use of Suzuki–Miyaura cross‐coupling reactions for the synthesis and functionalization of pyridine, indole, and quinoline derivatives—three classes of heterocycles known for their wide‐ranging biological and pharmacological significance. Although there are many reviews on Suzuki–Miyaura chemistry, a gap still exists in the various pathways to synthesize the N‐heterocycles under different conditions used, to achieve better yields. This gap is more significant since there is a greater possibility of pyridine, indole, and quinoline yielding a mixture of products due to the nitrogen coordination and regioselectivity issues. To address these, this review integrates various methodological advances, substrate‐specific challenges, and conditions to optimize the reaction. Thus, providing a systematic comparison of recent strategies employed for efficient coupling. Despite previous literature on broad surveys of coupling reactions, this review focuses on N‐heterocycle, such as pyridine, indole, and quinoline which have applications in various fields. This gives a clear perspective on the reactivity patterns, limitations, and optimization requirements of pyridines, indoles, and quinolines. This study examines advances in catalyst systems, reaction conditions, and substrate scope that have improved the efficiency, selectivity, and sustainability of these reactions. Special attention is given to environmentally friendly methodologies, including water‐mediated reactions, ligand‐free systems, and microwave‐assisted techniques. Recent studies on late‐stage functionalization and regioselective coupling are also critically discussed. Comparative tables highlight key trends in reaction yields, times, and optimal conditions. Beyond Suzuki–Miyaura coupling, several recent palladium‐catalyzed transformations have been included to emphasize the versatile role of palladium in heterocyclic chemistry. This article concludes by identifying current challenges and briefly exploring emerging alternatives, such as metal‐free approaches, offering guidance for future research in heterocyclic cross‐coupling chemistry.
K. et al. (Thu,) studied this question.