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Travel-time connectivity is a key factor in defining a process of the spatial reorganization of man's functional establishment. A case study relating highway development with the growth in wholesale activity for selected cities in the upper midwest of the United States indicates that, aside from being a good surrogate of transport efficiency, travel-time connectivity is also a good measure of the relative advantage of a given place in attracting to itself the centralization and specialization of human activity.
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Donald G. Janelle (1969) studied this question.
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