Why the study?
Pain aversiveness is a principal cause of suffering for patients with chronic pain, motivating efforts to investigate and modulate neural activity in brain circuits encoding pain unpleasantness.
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Design
Review
Offers circuit-based framework for chronic pain; leaves open targeted neuromodulation trials before clinical adoption.
Pain is a multidimensional experience with sensory-discriminative, affective-motivational, and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering for patients with chronic pain, motivating research and drug development efforts to investigate and modulate neural activity in the brain’s circuits encoding pain unpleasantness. Here, we review progress in understanding the organization of emotion, motivation, cognition, and descending modulation circuits for pain perception. We describe the molecularly defined neuron types that collectively shape pain multidimensionality and its aversive quality. We also review how pharmacological, stimulation, neurofeedback, surgical, and cognitive-behavioral interventions alter activity in these circuits to relieve chronic pain.
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Lindsay et al. (2021) studied this question.
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