Circ HIPK 3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells

Q: What does this research mean for the field?

circHIPK3 suppresses heparanase (HPSE) expression in bladder cancer cells by acting as a microRNA sponge for miR-558. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yawei Li; Fuxin Zheng; Xingyuan Xiao; Fei Xie; Dan Tao; Chao Huang; Dong Liu; Miao Wang; Liang Wang; Fuqing Zeng; Guosong Jiang

doi:10.15252/embr.201643581

August 9, 2017EMBO ReportsOpen Access

Circ HIPK 3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells

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Abstract

Mechanistic studies reveal that circHIPK3 contains two critical binding sites for the microRNA miR-558 and can abundantly sponge miR-558 to suppress the expression of heparanase (HPSE). Taken together, our findings provide evidence that circRNAs act as "microRNA sponges", and suggest a new therapeutic target for the treatment of bladder cancer.

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Li et al. (2017) studied this question.

synapsesocial.com/papers/6a04fcdaf94f4a51c26c447b https://doi.org/10.15252/embr.201643581

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Circ HIPK 3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells

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Circ HIPK 3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells

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Abstract

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