What does this research mean for the field?

circHIPK3 suppresses heparanase (HPSE) expression in bladder cancer cells by acting as a microRNA sponge for miR-558. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 9, 2017Open Access

Circ HIPK 3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells

Puntos clave

Los puntos clave no están disponibles para este artículo en este momento.

Resumen

Mechanistic studies reveal that circHIPK3 contains two critical binding sites for the microRNA miR-558 and can abundantly sponge miR-558 to suppress the expression of heparanase (HPSE). Taken together, our findings provide evidence that circRNAs act as "microRNA sponges", and suggest a new therapeutic target for the treatment of bladder cancer.

Leer artículo completoexternamente

Me gusta

Guardar

Ver artículo completo

Cite This Study

Li et al. (Wed,) studied this question.

synapsesocial.com/papers/6a04fcdaf94f4a51c26c447b https://doi.org/https://doi.org/10.15252/embr.201643581

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Circular RNAs: analysis, expression and potential functions2016 · 909 citations
2Scrambled exons1991 · 895 citations
3A Family of Human MicroRNA Genes from Miniature Inverted-Repeat Transposable Elements2007 · 286 citations
4ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data2010 · 15,601 citations
5A Genome-Wide Search for Promoters That Respond to Increased MYCN Reveals Both New Oncogenic and Tumor Suppressor MicroRNAs Associated with Aggressive Neuroblastoma2011 · 71 citations

Me gusta

Guardar

Ver artículo completo