Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 3, 2012Blood Coagulation & Fibrinolysis

Mean platelet volume is associated with culprit lesion severity and cardiac events in acute coronary syndromes without ST elevation

View Full Paper
Ask AI
Bookmark
Share

Key result

High mean platelet volume (>9.9 fl) in NSTE-ACS patients independently predicted 12-month major cardiac outcomes compared to lower MPV (HR 1.52; 95% CI 1.01-2.29; P=0.04).

Why the study?

Is high mean platelet volume associated with increased culprit lesion severity and major cardiac outcomes in patients with NSTE-ACS?

Population

344 patients with acute coronary syndrome with non-ST elevation who had significant coronary stenosis at…

Comparison

High mean platelet volume vs Low mean platelet volume

Design

Cohort

Follow-up

12 months

Authors

ADAbdullah DoğanFAFatih AksoyAİAtilla İçli

Discussion

Loading...

Member takes

Overview

High MPV may aid NSTE-ACS risk stratification; leaves open incremental value and need for prospective validation.

Study Design

Type

Cohort (n=344)

Structured PICO

Is high mean platelet volume associated with increased culprit lesion severity and major cardiac outcomes in patients with NSTE-ACS?

P
Population
344 patients with acute coronary syndrome with non-ST elevation (NSTE-ACS) who had significant coronary stenosis at least 50%
I
Intervention
High mean platelet volume (MPV >9.9 fl, upper tertile)
C
Comparator
Low mean platelet volume (MPV ≤9.9 fl, lower and mid tertile)
O
Outcome
Composite end-point of cardiac death, myocardial infarction (MI), recurrent angina or hospitalization at 12 monthscomposite

Main Result

Effect estimate: HR 1.52 (95% CI 1.01-2.29)

Absolute Event Rate: 39% vs 26%

p-value: p=0.04

Elevated mean platelet volume (>9.9 fl) on admission is an independent predictor of severe culprit stenosis and 12-month major cardiac outcomes in patients with NSTE-ACS.

Cite This Study

Doğan et al. (2012) conducted a cohort in Acute coronary syndrome with non-ST elevation (NSTE-ACS) (n=344). High mean platelet volume (>9.9 fl) vs. Low mean platelet volume (≤ 9.9 fl) was evaluated on Composite of cardiac death, myocardial infarction, recurrent angina or hospitalization (HR 1.52, 95% CI 1.01-2.29, p=0.04). High mean platelet volume (>9.9 fl) in NSTE-ACS patients independently predicted 12-month major cardiac outcomes compared to lower MPV (HR 1.52; 95% CI 1.01-2.29; P=0.04).

synapsesocial.com/papers/6a05009c22c8a0113de45d4ehttps://doi.org/10.1097/mbc.0b013e328352cb21
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome2011 · 50 citations
  2. 2Prognostic value of postprocedural mean platelet volume on one-year major cardiac outcomes in ST-elevation myocardial infarction after percutaneous coronary intervention2015 · 4 citations
  3. 3Mean platelet volume is associated with infarct size and microvascular obstruction estimated by cardiac magnetic resonance in ST segment elevation myocardial infarction2013 · 22 citations
  4. 4Prognostic implications of mean platelet volume on short- and long-term outcomes among patients with non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: A single-center large observational study2016 · 47 citations
  5. 5Impact of Platelet Volume on the Clinical Outcomes of Patients with Acute Coronary Syndrome.2019 · 12 citations