Key result
Long-term smoking was associated with an impaired increase in forearm vascular resistance after L-NMMA compared to nonsmokers (35.6% vs 118.8%, P<0.001), reflecting diminished nitric oxide tone.
Why the study?
Does smoking alter endothelium-dependent control of vascular tone and response to endothelin-1 in clinically healthy men?
Observational (n=45)
Does smoking alter endothelium-dependent control of vascular tone and response to endothelin-1 in clinically healthy men?
Absolute Event Rate: 35.6% vs 118.8%
p-value: p=<.001
Long-term smoking impairs nitric oxide-dependent basal vascular tone and endothelium-dependent vasodilation, while short-term smoking enhances endothelin-1-induced vasoconstriction, suggesting mechanisms for smoking-related atherogenesis.
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May link smoking to endothelial dysfunction in vascular disease; leaves open causal mechanisms and therapeutic targets.
Kiowski et al. (1994) conducted an observational in Clinically healthy smokers (n=45). Smoking (long-term and short-term) vs. Nonsmokers was evaluated on Increase of forearm vascular resistance (FVR) after L-NMMA (p=<.001). Long-term smoking was associated with an impaired increase in forearm vascular resistance after L-NMMA compared to nonsmokers (35.6% vs 118.8%, P<0.001), reflecting diminished nitric oxide tone.
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