Key result
Preoperative NT-proBNP levels did not differ significantly between non-survivors and survivors (p=0.162) regarding 30-day mortality after lower limb amputation.
Why the study?
Do preoperative NT-proBNP levels predict 30-day postoperative mortality in patients undergoing lower limb amputation for peripheral arterial disease?
Observational (n=19)
Yes
Do preoperative NT-proBNP levels predict 30-day postoperative mortality in patients undergoing lower limb amputation for peripheral arterial disease?
Absolute Event Rate: 15198% vs 3734%
p-value: p=0.162
Preoperative NT-proBNP levels are highly elevated in vascular amputees but do not significantly predict 30-day postoperative mortality in this small pilot study.
Preoperative NT-proBNP should not yet inform amputation risk assessment; larger prospective studies needed to clarify prognostic value.
OBJECTIVE: To determine preoperative ventricular function in vascular amputees by measuring N-terminal pro-brain natriuretic peptide (NT-proBNP) and to analyse the relationship between NT-proBNP levels and 30-day postoperative mortality. DESIGN: Prospective pilot study. SUBJECTS AND METHODS: In 19 patients planned for a lower limb amputation for non-reconstructable peripheral arterial disease NT-proBNP was measured the day before amputation. RESULTS: Four amputees died within 30 days after the amputation. In 17 of 19 patients NT-proBNP values were found more than 2 standard deviations above the age corrected reference value. Pre-amputation NT-proBNP levels did not differ significantly between non-survivors and survivors (P = 0.162). CONCLUSION: Preoperative NT-proBNP levels are not significantly related to 30-day mortality after lower limb amputation procedure. Preoperative NT-proBNP levels are very high, indicating that serious ventricular dysfunction may be present in vascular amputees.
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Riemersma et al. (2007) conducted an observational in Non-reconstructable peripheral arterial disease requiring lower limb amputation (n=19). Preoperative NT-proBNP measurement vs. Survivors vs Non-survivors was evaluated on Difference in preoperative NT-proBNP levels between 30-day non-survivors and survivors (p=0.162). Preoperative NT-proBNP levels did not differ significantly between non-survivors and survivors (p=0.162) regarding 30-day mortality after lower limb amputation.
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