Key result
Annual HbA1c fluctuation linked to higher PAD risk in poorly controlled T2D.
Why the study?
Glucose variability predicts cardiovascular events and mortality, but its association with peripheral artery disease has not been thoroughly investigated.
Does fluctuation in haemoglobin A1c value indicate higher risk for peripheral artery disease in patients with type 2 diabetes?
Cohort (n=4,144)
Does fluctuation in haemoglobin A1c value indicate higher risk for peripheral artery disease in patients with type 2 diabetes?
Answers are grounded in this paper and cite their sources.
Higher variability in annual HbA1c is associated with an increased risk of peripheral artery disease in patients with type 2 diabetes.
BACKGROUND: Glucose variability is predictive of cardiovascular events and all-cause mortality. However, the association between peripheral artery disease and glucose variability has not been thoroughly investigated. Therefore, the standard deviation of annual haemoglobin A1c was assessed in patients with type 2 diabetes for evaluating the different risks of peripheral artery disease. METHODS: A total of 4144 patients underwent an evaluation for the ankle-brachial index and the percentage of mean arterial pressure at the ankle. The first haemoglobin A1c record was retrospectively collected from each year until the ankle-brachial index measurement. CONCLUSION: Fluctuation in the haemoglobin A1c value indicates higher risk for peripheral artery disease in patients with type 2 diabetes and poor glucose control.
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I‐Te Lee (2020) conducted a cohort in Type 2 diabetes (n=4,144). Haemoglobin A1c variability was evaluated on Peripheral artery disease (p=0.014). Fluctuation in annual haemoglobin A1c values indicates a higher risk for peripheral artery disease in patients with type 2 diabetes and poor glucose control (P=0.014).
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