Key result
Early nebivolol preserves LV catecholamine response in post-MI rats partly via β3-adrenoceptor remodelling.
Why the study?
Does early nebivolol treatment improve cardiac function and preserve LV catecholamine response in rats with myocardial infarction?
Does early nebivolol treatment improve cardiac function and preserve LV catecholamine response in rats with myocardial infarction?
In a rat model of myocardial infarction, early nebivolol treatment preserves LV catecholamine response without worsening basal cardiac function.
Does not support early nebivolol in human MI yet; extends preclinical evidence on β3-remodelling preserving catecholamine response.
-AR transcription early MI. Despite its putative negative inotropic properties, nebivolol did not worsen cardiac function in basal conditions and preserved LV catecholamine response.
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Audigane et al. (2020) studied this question. Early nebivolol treatment in rats with myocardial infarction preserved left ventricular catecholamine response and did not worsen basal cardiac function, partly via β3-adrenoceptor remodelling.
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