Why the study?
Does the presence of multiple drug-drug interactions increase the risk of ischemic stroke and major bleeding in atrial fibrillation patients receiving DOACs?
Cohort (n=1,938)
No
Does the presence of multiple drug-drug interactions increase the risk of ischemic stroke and major bleeding in atrial fibrillation patients receiving DOACs?
In atrial fibrillation patients prescribed DOACs, having ≥ 2 drug-drug interactions is strongly associated with significantly increased risks of both ischemic stroke and hospitalization for major bleeding.
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Lee et al. (2021) conducted a cohort in Atrial fibrillation (n=1,938). DOACs with ≥ 2 potentially interacting drugs (DDIs) vs. DOACs without potentially interacting drugs was evaluated on Ischemic stroke (OR 18.68, 95% CI 6.22-55.27, p=<0.001).
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