Ultra-rare missense variants in the C-terminal lobe of calmodulin significantly increased the risk of schizophrenia (OR 5.62) and altered calcium binding affinity and CaV1.2 regulation.
Observational (n=121,570)
Yes
Do calmodulin variants increase schizophrenia risk?
Calmodulin variants may increase the risk of schizophrenia, potentially through effects on ion channel gating.
Effect estimate: OR 5.62 (95% CI 1.8-19)
Absolute Event Rate: 0.029% vs 0.0051%
p-value: p=0.0036
2 gating. Together, this study suggests that consequences of calmodulin variants include increased schizophrenia risk.
Jensen et al. (Sat,) conducted a observational in Schizophrenia (n=121,570). Calmodulin C-lobe missense variants vs. Control individuals was evaluated on Schizophrenia risk associated with calmodulin C-lobe missense variants (OR 5.62, 95% CI 1.8-19, p=0.0036). Ultra-rare missense variants in the C-terminal lobe of calmodulin significantly increased the risk of schizophrenia (OR 5.62) and altered calcium binding affinity and CaV1.2 regulation.
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