Key result
Chronic atrial fibrillation was associated with increased baseline platelet P-selectin expression compared to sinus rhythm (1329 ± 81 vs 968 ± 108 BC; P < 0.05).
Why the study?
Does chronic atrial fibrillation increase platelet P-selectin expression compared to sinus rhythm?
Cross-Sectional (n=30)
Does chronic atrial fibrillation increase platelet P-selectin expression compared to sinus rhythm?
Answers are grounded in this paper and cite their sources.
Chronic atrial fibrillation is associated with increased platelet P-selectin expression, suggesting a potential mechanism for thromboembolic complications that may not be addressed by aspirin.
Previous studies have shown that platelets are activated during atrial fibrillation (AF). However, prophylactic therapy with aspirin is not associated with a reduction of thromboembolic complications in patients with AF. Stimulation of platelet thrombin and ADP receptors causes a release of P‐selectin, which is not affected by aspirin. The purpose of this study was to assess the influence of AF on platelet P‐selectin expression. Blood samples from 30 patients were studied ex vivo. Nineteen patients had chronic AF (> 3 months), 11 patients were in sinus rhythm (SR). P‐selectin expression was determined by flow cytometry (antibody binding capacity [BC]) at baseline and after platelet stimulation with adenosine diphosphate (ADP) and thrombin receptor activating peptide (TRAP). To determine the effect of heart rate and atrial pressure (RAP), measurements were repeated after 10 minutes of ventricular pacing (120 beats/min) in patients with SR. P‐selectin expression was increased in patients with AF at baseline (AF: 1329 ±81 BC vs SR: 968 ± 108 BC; P < 0.05) and after stimulation with ADP (AF: 1445 ± 101 BC vs SR: 1061 ± 109 BC; P < 0.05) and TRAP (AF: 13783 ± 2442 BC vs SR: 5977 ± 800 BC; P < 0.05). RAP (2.0 ± 0.5 vs 6.0 ± 0.8 mmHg; P < 0.01) and atrial rate (75 ± 5 vs 114 ± 5 beats/min; P < 0.001) increased during ventricular pacing. However, P‐selectin levels remained stable. AF was accompanied by increased P‐selectin expression. In contrast, increased ventricular rate and elevated atrial pressure alone had no effect on platelet activity. Further studies are needed to determine if platelet ADP receptor inhibitors offer a therapeutic benefit in patients with AF.
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GOETTE et al. (2000) conducted a cross-sectional in Chronic Atrial Fibrillation (n=30). Chronic Atrial Fibrillation vs. Sinus Rhythm was evaluated on Platelet P-selectin expression at baseline (antibody binding capacity [BC]) (p=< 0.05). Chronic atrial fibrillation was associated with increased baseline platelet P-selectin expression compared to sinus rhythm (1329 ± 81 vs 968 ± 108 BC; P < 0.05).
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