This review emphasizes the importance of sex-specific pathophysiological mechanisms, including differences in calcification and fibrosis, in the development and progression of fibrocalcific aortic valve stenosis.
Requires sex-specific evaluation in aortic stenosis; extends fibrocalcific phenotype understanding but leaves therapeutic targeting open.
Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.
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Sritharen et al. (2017) conducted a review in Fibrocalcific aortic valve stenosis.
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