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认知障碍 APOE4 携带者循环血浆 sPDGFRβ 水平升高 | Synapse

May 14, 2026GeroScience0 citationsOpen Access

认知受损 APOE4 携带者循环血浆 sPDGFRβ 水平升高

ASAbhay P. SagareUniversity of Southern California TLTrevor LohmanUniversity of Southern California IRIvan RamirezUniversity of Southern California

Key Points

本研究旨在评估血浆 sPDGFRβ 作为伴有认知受损的 APOE4 携带者脑损伤生物标志物的作用。
分析了 APOE4 携带者循环血浆中的 sPDGFRβ 水平
将该水平与其他认知和病理标志物（如 pTau217）进行了比较
血浆 sPDGFRβ 水平升高与 APOE4 携带者的认知受损相关
提示其具有作为评估血脑屏障和周细胞损伤生物标志物的潜力

Abstract

比值和 pTau217。因此，我们的数据表明血浆 sPDGFRβ 是 APOE4 携带者脑周细胞/BBB 损伤的有用生物标志物。

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Cite This Study

Sagare et al. (Tue,) 对这一问题进行了研究。

synapsesocial.com/papers/6a05661aa550a87e60a1e299 https://doi.org/https://doi.org/10.1007/s11357-026-02291-y

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