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May 12, 2026GeroScienceOpen Access

Elevated levels of circulating plasma sPDGFRβ in cognitively impaired APOE4 carriers

Abhay P. Sagare Trevor Lohman Ivan Ramirez Elizabeth B. Joe Michael G. Harrington Helena C. Chui L Schneider Hussein N. Yassine John M. Ringman Arthur W. Toga Daniel A. Nation Berislav V. Zloković

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Key Points

This research aims to assess the role of plasma sPDGFRβ as a biomarker for brain damage in APOE4 carriers with cognitive impairment.
Analyzed circulating plasma levels of sPDGFRβ in APOE4 carriers
Compared levels with other cognitive and pathological markers, such as pTau217
Elevated plasma sPDGFRβ levels correlate with cognitive impairment in APOE4 carriers
Suggests potential as a biomarker for assessing blood-brain barrier and pericyte damage

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Implication

Finds plasma spdgfrb is a biomarker for brain damage in Apoe4 carriers, suggesting diagnostic potential.

Abstract

ratio and pTau217. Thus, our data suggest that plasma sPDGFRβ is a useful biomarker of brain pericytes/BBB damage in APOE4 carriers.

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Cite This Study

Sagare et al. (2026) studied this question.

synapsesocial.com/papers/6a05661aa550a87e60a1e299 https://doi.org/10.1007/s11357-026-02291-y

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