Pixel-based AFM-IR uncovers nanoscale lipid remodeling in MPNST cells

Key Points

• This research aims to understand how lipids are reorganized at a nanoscale in MPNST cells using advanced spectroscopy techniques.
• Integrated band-based spectroscopy with pixel-based AFM-IR analysis to examine lipid abundance and organization.
• Semi-quantification of lipid species to observe nanoscale changes.
• Focus on MPNST-derived cells.
• Identified significant variations in lipid organization in MPNST cells.
• Quantified different lipid species abundance, confirming reorganization.
• Notable differences in lipid packing were observed at the nanoscale.