Combining Photo-CIDNP and Long-Lived Spin States Enables High-Contrast Detection of Weak Protein-Ligand Interactions

Matthias Bütikofer; Anna Sonnefeld; Gabriela  Ruth Stadler; Felix Torres; Geoffrey Bodenhausen; Kirill Sheberstov; Roland Riek

doi:10.1039/d6cp00658b

January 1, 2026Physical Chemistry Chemical PhysicsOpen Access

Combining Photo-CIDNP and Long-Lived Spin States Enables High-Contrast Detection of Weak Protein-Ligand Interactions

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Key Points

The aim is to investigate how combining photo-CIDNP with long-lived spin states enhances detection of weak protein-ligand interactions.
Utilized photo-chemically induced dynamic nuclear polarization (photo-CIDNP) with nuclear magnetic resonance (NMR) techniques.
Combined long-lived spin states (LLS) to achieve extended lifetimes and signal enhancements in measurements.
Achieved significant signal enhancements resulting in better detection of weak protein-ligand interactions.
Extended lifetimes of signals allowed for better analysis and interpretation of NMR data.

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Implication

Demonstrates enhanced detection of weak protein-ligand interactions, suggesting improved NMR techniques.

Abstract

Photo-chemically induced dynamic nuclear polarization (photo-CIDNP) and long-lived spin states (LLS) are two nuclear magnetic resonance (NMR) techniques that can be combined to achieve large signal enhancements and extended lifetimes...

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Bütikofer et al. (2026) studied this question.

synapsesocial.com/papers/6a056695a550a87e60a1e928 https://doi.org/10.1039/d6cp00658b

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Combining Photo-CIDNP and Long-Lived Spin States Enables High-Contrast Detection of Weak Protein-Ligand Interactions

Key Points

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Abstract

Discussion

Cite This Study

Combining Photo-CIDNP and Long-Lived Spin States Enables High-Contrast Detection of Weak Protein-Ligand Interactions

Key Points

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Implication

Abstract

Discussion

Cite This Study

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