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May 14, 2026PLoS ONE0 citationsOpen Access

Impact of Cannabidiol on Hyperglycemic Zebrafish Models

The impact of cannabidiol (CBD) in hyperglycemic zebrafish (Danio rerio)

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Authors

EMElizabeth McCarthyLGLeehy GertnerJCJustin Ciocirlan

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Overview

Randomized trial assesses cannabidiol's effects on visual function in hyperglycemic zebrafish, suggesting broader implications for diabetes management.

Key Points

  • This research evaluates whether cannabidiol can alleviate visual deficits caused by hyperglycemia in a zebrafish model of Type 2 Diabetes Mellitus.
  • Examined the effects of CBD (5 mg/L) during a 4-week hyperglycemic induction in zebrafish models.
  • Utilized behavioral (optomotor response), molecular (RT-qPCR and Western Blot), and physiological (electroretinogram) techniques.
  • Measured retinal responses and blood glucose levels before and after CBD co-exposure.
  • CBD co-exposure improved optomotor responses but did not significantly reduce blood glucose levels.
  • Electroretinogram showed delayed response times in photoreceptor activity with CBD but did not restore amplitude deficits.
  • Retinal protein analysis indicated decreased claudin-5 and increased occludin levels in hyperglycemic fish with CBD.

Cite This Study

McCarthy et al. (2026) studied this question.

synapsesocial.com/papers/6a0566bda550a87e60a1ec0fhttps://doi.org/10.1371/journal.pone.0348975
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