Dynamic Mechanical Cues from Hydrogels Promote Osteogenesis via the YAP Signaling Pathway

Hai Liu; Lulong Zhao; Weilun Pan; Songlang Liu; Hongxing Liao; Jun Hu; Liqiong Liao

doi:10.1039/d6tb00164e

January 1, 2026Journal of Materials Chemistry B

Dynamic Mechanical Cues from Hydrogels Promote Osteogenesis via the YAP Signaling Pathway

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to explore how dynamic mechanical properties of hydrogels can enhance bone formation through the YAP signaling pathway.
Developed a photo-tunable dynamic stiffening hydrogel to mimic native bone matrix properties.
Assessed osteogenic responses in cell cultures exposed to dynamically stiffening conditions.
The dynamic stiffening hydrogel significantly increased osteogenesis compared to static conditions.
Activation of the YAP signaling pathway was confirmed to mediate osteogenesis in response to mechanical cues.

Implication

Examines hydrogels promoting osteogenesis through YAP signaling in bone development, suggesting new biomaterials.

Abstract

The native bone matrix stiffens dynamically during development, presenting a critical mechanical cue that static biomaterials cannot effectively mimic. To address this, a photo-tunable dynamic stiffening hydrogel was developed using...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a0566d9a550a87e60a1ec2e https://doi.org/10.1039/d6tb00164e

View Full Paper

Ask AI

Bookmark

Share

Dynamic Mechanical Cues from Hydrogels Promote Osteogenesis via the YAP Signaling Pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Dynamic Mechanical Cues from Hydrogels Promote Osteogenesis via the YAP Signaling Pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading