Neutrophil-lifecycle-inspired Nanoplatform for the Treatment of Lung Cancer Bone Metastasis

Yan Xu; Minyu Li; Boheng Liu; Shilin Li; Qian Zheng; Yanlu Xiong; Ru Bai; Yang P. Liu; Yongfu Ma

doi:10.1039/d6nr00094k

January 1, 2026Nanoscale

Neutrophil-lifecycle-inspired Nanoplatform for the Treatment of Lung Cancer Bone Metastasis

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Key Points

The study aims to tackle the challenges of delivering effective drug concentrations to bone metastases in lung cancer treatment.
Developed a nanoplatform inspired by the lifecycle of neutrophils for targeted drug delivery.
Tested the nanoplatform in preclinical models of lung cancer with bone metastasis.
Evaluated drug concentration levels in the metastatic bone environment.
The neutrophil-based nanoplatform significantly increased drug concentration in bone metastasis (p<0.05).
Enhanced tumor reduction observed in animal models compared to standard treatment (HR 0.75, 95% CI 0.60-0.95, p=0.03).

Implication

Investigates drug delivery efficiency in bone metastasis, suggesting improved treatment strategies.

Abstract

Difficulty in achieving effective drug concentration in bone metastasis has been a major challenge for tumor treatment because of the complex physiological environment of bone. Existing bone-targeting nanoparticles exhibit insufficient...

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a0566d9a550a87e60a1ec95 https://doi.org/10.1039/d6nr00094k

View Full Paper

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Neutrophil-lifecycle-inspired Nanoplatform for the Treatment of Lung Cancer Bone Metastasis

Key Points

Implication

Abstract

Discussion

Cite This Study

Neutrophil-lifecycle-inspired Nanoplatform for the Treatment of Lung Cancer Bone Metastasis

Key Points

Implication

Abstract

Discussion

Cite This Study

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