Electrochemically enabled synthesis of oxathiazinane via a radical cyclization cascade

Zhuo-Qi Lin; Zhi-Long Lei; Xiu‐Jin Meng; Wen-Bing Wang; Hai-Tao Tang; Ying-Ming Pan

doi:10.1039/d6cc01416j

January 1, 2026Chemical Communications

Electrochemically enabled synthesis of oxathiazinane via a radical cyclization cascade

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Key Points

This research aims to develop an electrochemical method for synthesizing oxathiazinane via radical cyclization.
Utilized 2-hydroxy-1-ethanethiol and styryl azides for synthesizing oxathiazinane.
Generated sulfur radicals in situ without the need for oxidants or catalysts.
Focused on achieving excellent regioselectivity.
Successfully synthesized oxathiazinane with high regioselectivity.
Electrochemical method showed significant effectiveness compared to traditional methods.

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Implication

Demonstrates electrochemical alkene thiooxygenation, suggesting a novel synthetic route to oxathiazinane.

Abstract

We report an electrochemical alkene thiooxygenation using 2-hydroxy-1-ethanethiol and styryl azides to access oxathiazinane. This method generates sulfur radicals in situ without oxidants or catalysts, offering excellent regioselectivity and addressing...

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Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a0566d9a550a87e60a1ed23 https://doi.org/10.1039/d6cc01416j

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Electrochemically enabled synthesis of oxathiazinane via a radical cyclization cascade

Key Points

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Implication

Abstract

Discussion

Cite This Study

Electrochemically enabled synthesis of oxathiazinane via a radical cyclization cascade

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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