The Global Academic Landscape of Primary Adrenal Insufficiency Research From 2000 to 2023: A Bibliometric Analysis

Background Primary adrenal insufficiency (PAI) is a rare but life‐threatening endocrine disorder with diverse etiologies. Although research activity has expanded in recent decades, a comprehensive bibliometric analysis of global PAI scholarship has been lacking. Methods Publications related to PAI from 2000 to 2023 were retrieved from the Web of Science Core Collection. Bibliometric analyses were performed using VOSviewer and Scimago Graphica to evaluate global contributions, collaboration patterns, and thematic trends. Results A total of 6413 publications were identified, showing steady growth with peak output in 2022. The United States, England, and Italy were the leading contributors, while China showed rapid growth in recent years. The University of London and AP‐HP were among the most productive institutions. Keyword and co‐citation analyses revealed major research foci in adrenal crisis, autoimmune Addison’s disease, congenital adrenal hyperplasia, and emerging topics such as immune checkpoint inhibitor–related PAI, COVID‐19–associated adrenal dysfunction, and genetic risk factors. Conclusions PAI research has grown significantly over the past 2 decades. These evolving trajectories highlight shifting priorities toward genetics, immune regulation, and treatment advancements, reflecting an increasingly interdisciplinary field.