Conformational Features of N -Trifluoromethyl Amides and Thioamides

Ryu Yamasaki; Yuta Nozaka; Ami Nagai; Ai Ito; Masatoshi Kawahata; Iwao Okamoto

doi:10.1039/d6qo00428h

January 1, 2026Organic Chemistry Frontiers

Conformational Features of N -Trifluoromethyl Amides and Thioamides

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Key Points

This research aims to analyze the conformational characteristics of N-trifluoromethyl (N-CF₃) amides and thioamides.
Conducted X-ray analyses to examine structural features.
Utilized VT NMR to assess rotational dynamics.
Demonstrated lower rotational barriers in N-trifluoromethyl amides and thioamides.
Observed a generally reduced cis population in these compounds.

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Implication

Investigation reveals structural features affecting rotations in N-trifluoromethyl compounds, suggesting unique characteristics.

Abstract

We investigated the structural and conformational features of N -trifluoromethyl ( N -CF₃) (thio)amides using X ray and VT NMR analyses. These compounds showed lower rotational barriers and generally reduced cis populations compared...

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Cite This Study

Yamasaki et al. (2026) studied this question.

synapsesocial.com/papers/6a056751a550a87e60a1f4ee https://doi.org/10.1039/d6qo00428h

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Conformational Features of N -Trifluoromethyl Amides and Thioamides

Key Points

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Implication

Abstract

Discussion

Cite This Study

Conformational Features of N -Trifluoromethyl Amides and Thioamides

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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