Induction of oxidative stress tolerance by ultrasonic exposure extends the lifespan of C. elegans

Reactive oxygen species (ROS), the cause of oxidative stress, are produced throughout the body, and their excess accumulation leads to oxidative stress. Oxidative stress is involved in aging-related diseases such as dementia and diabetes, as well as in lifespan. In this study, we investigated the effects of ultrasonic exposure on the life span and antioxidant capacity of C. elegans. A culture dish was placed at a distance of 70 mm from a planar transducer, 35 mm in diameter, operating at a 2-MHz frequency, and filled with degassed water at room temperature to the height of the dish. The dish was then exposed to ultrasound. As a result, we confirmed that the life span of C. elegans was extended and its antioxidant capacity was improved. In this study, we also focused on the mechanism by which ultrasonic exposure enhances antioxidant capacity and confirmed that Piezo1, a mechanosensitive ion channel, is involved in this process.