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May 11, 2026Journal of Addictive Diseases

Association of GLP-1 receptor agonist use with long-term outcomes in patients with opioid use disorder

Dhairya A. Lakhani Wanhong Zheng

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Key Points

The aim is to assess the long-term effects of GLP-1 receptor agonists in patients with opioid use disorder.
Examined long-term outcomes associated with GLP-1 receptor agonist use among patients with opioid use disorder.
Assessed mortality rates, overdose risks, and healthcare utilization metrics in the patient population.
GLP-1 receptor agonist use was linked to lower mortality rates, with significant statistical support (p<0.001).
Reduction in overdose risk and healthcare utilization was also observed, indicating beneficial outcomes from GLP-1RA therapy.

Implication

Investigates GLP-1 receptor agonists' impact on outcomes in opioid use disorder, suggesting therapeutic potential.

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Cite This Study

Lakhani et al. (2026) studied this question.

synapsesocial.com/papers/6a05677ca550a87e60a1f8e7 https://doi.org/10.1080/10550887.2026.2653228

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Association of <scp>GLP</scp> ‐1 Receptor Agonist Use With Safety Outcomes in Individuals With Opioid Use Disorder: A Target Trial EmulationCohort Study · 2026 · 1 citations
21657-P: Concomitant Use of GLP-1RAs and Chronic Opioids and Risk of Opioid Overdose and Substance Use DisordersCohort Study · 2026
3A rapid review of the effects of GLP-1 receptor agonists on opioid and stimulant use-related outcomesReview · 2026 · 1 citations
4Exploratory associations between co-occurring opioid and alcohol use disorders and GIP/GLP-1 receptor agonist treatmentCohort Study · 2026 · 2 citations
5Association of glucagon-like peptide-1 receptor agonist use with clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes.Original Research · 2026

More related papers

GLP-1 RAs in Substance Use Disorders: Emerging Evidence and Future Directions2026
1431-P: Synergistic Effect of GLP-1 Receptor Agonists and Opioids on Gastric Emptying and Symptom Burden: A Propensity-Matched Multicenter Analysis2026
Association between GLP-1 receptor agonist use and substance use disorders among individuals with type 2 diabetes or obesity: a nested case-control study in the All of Us research program2026

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