Commonalities in frailty and psychopathology predict chronotype across severe mental disorders from a comorbidity perspective

BACKGROUND: Individuals with severe mental illness (SMI) have increased risk of physical comorbidities, linked to worse outcomes such as greater psychopathology, frailty, and neurocognitive impairment. Mechanisms underlying this burden remain unclear. This study examined whether frailty and psychopathology predict evening chronotype, especially in SMI with comorbidities. METHODS: = 60). Measures included psychopathology, frailty, chronotype, neurocognitive and functional performance, and hematological biomarkers. RESULTS: < 0.05-0.01); in controls, frailty and performance did so (p < 0.05). CONCLUSIONS: Psychopathological and hematological profiles are associated with chronotype and may help identify subgroups for chronobiology-informed interventions. These findings support more personalized treatment approaches.