Review offers guidance on treating acne in cystic fibrosis patients using isotretinoin and managing vitamin A levels.
A 16‐year‐old boy with cystic fibrosis (CF) on fat‐soluble vitamin (including vitamin A) supplementation develops severe acne. He is commenced on isotretinoin, a vitamin A derivative. The package insert says that vitamin A supplementation should be stopped, presenting a therapeutic dilemma. We review the literature and previous reports of isotretinoin use in patients with CF to provide guidance on how to successfully treat acne while minimizing adverse effects, including in patients on genomodulatory therapy.
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O’Mahony et al. (2026) studied this question.
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