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May 14, 2026Physiology

Decipher the molecular mechanism: The role of stromal vascular cells in mediating rat visceral adipose tissue dysfunction in alcohol-associated liver disease

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Authors

WAWeilun AiAKArul Daniel John KathiravanVSViswanathan Saraswathi

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Overview

Randomized trial evaluates the impact of ethanol on adipose tissue dysfunction in rats, suggesting mechanisms of inflammation and fibrosis.

Key Points

  • This research aims to uncover how stromal vascular cells contribute to inflammation and fibrosis in visceral adipose tissue due to alcohol exposure.
  • Male wild-type Wistar rats were fed a 6.7% ethanol diet or isocaloric control for 6 weeks.
  • Adipose tissue samples were collected and analyzed for adipocyte size and fibrosis using staining techniques.
  • RNA sequencing and corresponding validations were performed on primary SVCs isolated from visceral adipose tissue.
  • Chronic alcohol feeding decreased adipocyte size (P<0.01) and increased collagen deposition (P<0.05).
  • RNA sequencing identified 54 differentially expressed genes post-alcohol exposure (adjusted P<0.05).
  • The P2RY2-IL1b axis and TGFb-Col8a1 signaling pathway were activated in SVCs from alcohol-fed rats, promoting inflammation and fibrosis.

Cite This Study

Ai et al. (2026) studied this question.

synapsesocial.com/papers/6a0567bca550a87e60a1fe63https://doi.org/10.1152/physiol.2026.41.s1.2300839
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