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This study aims to redefine the kidney's role beyond filtration to include its function in neuro-inflammatory processes affected by chronic stress.

May 14, 2026Open Access

Beyond filtration: The kidney as a neuro-inflammatory regulator under chronic stress and allostatic load

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Theoretical analysis characterizes the kidney's role in neuro-inflammation and chronic stress mechanisms, suggesting new perspectives for nephrology.

This study aims to redefine the kidney's role beyond filtration to include its function in neuro-inflammatory processes affected by chronic stress.
Conceptual analysis of existing literature in nephrology, stress neurobiology, and immunology.
Synthesis of current findings to create the Neuro-Renal Allostatic Load Model (NRALM).
Prolonged activation of the HPA axis and sympathetic nervous system leads to renal microinflammation and worsens chronic kidney disease (CKD).
Established a link between chronic psychosocial stress and renal dysfunction via endothelial dysfunction and oxidative stress.
Introduced the NRALM, which integrates stress assessment in renal disease progression models.

Oxbridge Journal (2026) studied this question.

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Theoretical analysis characterizes the kidney's role in neuro-inflammation and chronic stress mechanisms, suggesting new perspectives for nephrology.