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This study investigates the effects of indole-3-acetic acid on angiotensin II-induced hypertension and organ injury.

May 14, 2026Physiology

A Gut Microbial Metabolite Attenuates Angiotensin II–Induced Hypertension and Organ Injury via Inhibition of Endothelin-1 Signaling

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This study investigates the effects of indole-3-acetic acid on angiotensin II-induced hypertension and organ injury.
Mice aortic endothelial cells treated with graded concentrations of IAA (0.01–100 nM) and stimulated with Ang II (100 nM).
Male Sprague Dawley rats were infused with Ang II (700 ng/kg/min) and orally treated with IAA (5, 10, or 20 mg/kg/day) for 14 days.
Vascular assessments included blood pressure monitoring, plasma ET-1 levels, and histological evaluation of renal tissues.
IAA at 10 and 20 mg/kg significantly reduced Ang II-induced hypertension (P<0.01) and preserved vasodilation responses.
IAA significantly decreased ET-1 production and vascular expression (P<0.05) in both plasma and tissues, confirming systemic inhibition.
Renal interstitial fibrosis was significantly decreased with IAA treatment.

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Randomized trial shows that indole-3-acetic acid reduces hypertension in male rats, suggesting new treatment avenues.

Ezewudo et al. (2026) studied this question.

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