Global adoption of TRI-SCORE digital tools for the risk stratification of patients with tricuspid regurgitation

BACKGROUND: The TRI-SCORE is a dedicated risk-stratification tool for patients with isolated severe tricuspid regurgitation (TR) that is freely accessible via a web-based platform or mobile application. AIMS: To evaluate the global uptake of the TRI-SCORE and to describe the clinical characteristics of patients considered for intervention. METHODS: We collected all TRI-SCORE calculations and related parameters entered by users into the web-based calculator or mobile application between June 2024 and June 2025, along with the users' geographic location. The clinical profiles derived from these data were compared with those of the TRIGISTRY cohort. RESULTS: Overall, 36,001 calculations were recorded across 117 countries, with 83% performed through the web-based platform. Most patients were aged≥70 years (70%), 58% were women and 70% had atrial fibrillation or flutter. TR was functional in 73% of cases. Patients were generally severely symptomatic (58% in New York Heart Association class III-IV, 58% with right heart failure signs) and many presented with advanced disease stages, with 33% and 27% falling into intermediate (4-5 points) and high (≥6 points) TRI-SCORE categories, respectively. Patient profiles were broadly consistent with those in TRIGISTRY, although left ventricular, hepatic and renal dysfunction were less commonly encountered. CONCLUSION: These findings demonstrate the widespread adoption of the TRI-SCORE through free, user-friendly digital platforms and suggest its potential utility as a tool to monitor disease stage when considering interventions in patients with TR.