⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

December 28, 2017NeuronOpen Access

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1

Christian Madry Vasiliki Kyrargyri I. Lorena Arancibia‐Cárcamo Renaud Jolivet Shinichi Kohsaka Robert M. Bryan David Attwell

View Full Paper

Ask AI

Bookmark

Share

Abstract

loss being needed for inflammasome assembly. Thus, microglial immune surveillance and cytokine release require THIK-1 channel activity.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Madry et al. (2017) studied this question.

synapsesocial.com/papers/6a0584d903ce5286c2a21db7 https://doi.org/10.1016/j.neuron.2017.12.002

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X<sub>7</sub> receptor‐mediated IL‐1β releaseOriginal Research · 2008 · 74 citations
2Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation <i>in vitro</i>In Vitro Study · 2003 · 203 citations
3The mammalian gene function resource: the international knockout mouse consortiumOriginal Research · 2012 · 312 citations
4Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged MiceOriginal Research · 2015 · 43 citations
5Enhanced synaptic connectivity and epilepsy in C1q knockout miceOriginal Research · 2010 · 364 citations

More related papers

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques2015
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation2012
Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current2008

More from Neuron

Circuit mechanisms of psychotic symptoms across disordersThu,
Tau phosphorylation from neuronal adaptation to Alzheimer’s diseaseThu,