Key result
While elevated cardiac troponin usually reflects true myocardial injury, true false positive results can rarely occur due to assay interference from heterophile antibodies, which have an estimated population prevalence of 0.2% to 3.7%.
Clinicians must differentiate between true myocardial injury and rare assay interference when interpreting elevated high-sensitivity cardiac troponin levels.
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Januzzi et al. (2020) conducted an editorial in Myocardial injury. Cardiac troponin assays was evaluated. While elevated cardiac troponin usually reflects true myocardial injury, true false positive results can rarely occur due to assay interference from heterophile antibodies, which have an estimated population prevalence of 0.2% to 3.7%.
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