Key result
Repeat digoxin measurement using an assay unaffected by human antimouse antibodies revealed a true level of 1.3 ng/mL, correcting a falsely elevated initial level of 45.9 ng/mL.
Population
77-year-old man admitted to the intensive care unit with a falsely elevated serum digoxin level
Comparison
Digoxin measurement using an assay not affected… vs Older digoxin assay affected by human antimouse…
Design
Case_report
Authors
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Alerts clinicians to potential digoxin assay interference by antimouse antibodies; case extends documentation of immunoassay artifacts.
Case Report (n=1)
Absolute Event Rate: 1.3% vs 45.9%
Clinicians should be aware of possible human antimouse antibody interference causing falsely elevated digoxin levels in older assays to avoid unnecessary interventions.
Ingels et al. (2000) conducted a case report in Falsely elevated digoxin level (n=1). Digoxin assay unaffected by human antimouse antibodies vs. Older digoxin assay (affected by human antimouse antibodies) was evaluated on Serum digoxin level (ng/mL). Repeat digoxin measurement using an assay unaffected by human antimouse antibodies revealed a true level of 1.3 ng/mL, correcting a falsely elevated initial level of 45.9 ng/mL.
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