May 14, 2026Journal of the American College of CardiologyOpen Access

Relationship of Ventricular Morphology and Atrioventricular Valve Function to Long-Term Outcomes Following Fontan Procedures

Q: What are the key findings of this study?

Presence of a morphologic right ventricle was an independent risk factor for reduced transplant and takedown free survival following the Fontan procedure (HR 2.4; p=0.008).

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Fontan procedure outcomes (n=1162). Intervention: Morphologic right ventricle vs. Non-morphologic right ventricle. Primary outcome: Transplant and takedown free survival (HR 2.4, p=0.008).

View Full Paper

Ask AI

Bookmark

Key result

Systemic RV linked to ~140% higher risk of Fontan takedown or transplant.

HR 2.4
P=0.008
n=1,162

Why the study?

Does morphologic right ventricle morphology worsen long-term outcomes following a Fontan operation?

Population

1,162 patients who underwent the Fontan procedure between 1985 and 2018 at a single center

Comparison

Morphologic right ventricle (RV) vs Non-morphologic right ventricle

Design

Cohort

Follow-up

Up to 25 years

Authors

JMJiyong MoonTwitter (United States)LSLi ShenHubei University of Medicine DLDonald S. LikoskyCardiac Surgery

Discussion

Member takes

Implication

Morphologic right ventricle is associated with worse long-term survival and progressive atrioventricular valve regurgitation following the Fontan procedure.

Key Points

This study aims to explore the impact of ventricular morphology and atrioventricular valve function on long-term outcomes after Fontan procedures.
Single-center retrospective study of 1,162 patients who underwent Fontan from 1985 to 2018.
Analysis of transplant and takedown free survival, ventricular, and atrioventricular valve dysfunction.
Follow-up data sourced from the National Death Index and Scientific Registry of Transplant Recipients.
99% follow-up rate with a morphologic right ventricle (RV) observed in 58% of patients.
Transplant and takedown free survival rates were 91%, 75%, and 71% at 10, 20, and 25 years, respectively.
Morphologic RV identified as an independent risk factor for poor survival (HR: 2.4; p=0.008) and odds ratio for AVVR's contribution to ventricular dysfunction was 4.3 (95% CI: 2.7-6.7; p<0.001).

Study Design

Type

Cohort (n=1,162)

Multicenter

Structured PICO

Does morphologic right ventricle morphology worsen long-term outcomes following a Fontan operation?

Population

1,162 patients who underwent the Fontan procedure at a single center between 1985 and 2018, evaluated for long-term survival and ventricular function.

Exposure

Morphologic right ventricle (RV)

Comparator

Non-morphologic right ventricle

Outcome

Transplant and takedown free survivalhard clinical

Main Result

Hazard Ratio: 2.4

p-value: p=0.008

Morphologic right ventricle is associated with worse long-term survival and progressive atrioventricular valve regurgitation following the Fontan procedure.

Cite This Study

Moon et al. (2020) conducted a cohort in Fontan procedure outcomes (n=1,162). Morphologic right ventricle vs. Non-morphologic right ventricle was evaluated on Transplant and takedown free survival (HR 2.4, p=0.008). Presence of a morphologic right ventricle was an independent risk factor for reduced transplant and takedown free survival following the Fontan procedure (HR 2.4; p=0.008).

synapsesocial.com/papers/6a05e7e467524563d62543d2 https://doi.org/10.1016/j.jacc.2020.05.059

View Full Paper

Ask AI

Bookmark

Implication

Morphologic right ventricle is associated with worse long-term survival and progressive atrioventricular valve regurgitation following the Fontan procedure.

Relationship of Ventricular Morphology and Atrioventricular Valve Function to Long-Term Outcomes Following Fontan Procedures

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Relationship of Ventricular Morphology and Atrioventricular Valve Function to Long-Term Outcomes Following Fontan Procedures

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider