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October 1, 2011Annals of Noninvasive Electrocardiology28 citationsOpen Access

Heart Rate Variability and Heart Rate Turbulence in Hypothyroidism before and after Treatment

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Why the study?

Does L-thyroxine therapy improve heart rate variability and heart rate turbulence in patients with hypothyroidism?

Population

71 participants: 40 hypothyroid patients and 31 healthy controls.

Comparison

L-thyroxine for 6 months vs Healthy controls and pre-treatment baseline

Design

Cohort

Follow-up

6 months

Authors

AÇAtaç ÇelikPAPelin AytanHDHüseyin Dursun

Discussion

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Overview

L-thyroxine may not restore autonomic function in hypothyroidism; leaves open need for longer-term or adjunctive intervention trials.

Structured PICO

Does L-thyroxine therapy improve heart rate variability and heart rate turbulence in patients with hypothyroidism?

P
Population
71 participants: 40 hypothyroid patients (mean age 48 ± 13, 4 male) and 31 healthy controls (mean age 51 ± 12, 3 male).
I
Intervention
L-thyroxine (thyroid replacement therapy) for 6 months
C
Comparator
Healthy controls (for baseline comparison) and pre-treatment baseline (for treatment effect)
O
Outcome
Changes in heart rate variability (HRV) and heart rate turbulence (HRT) parameters (SDNN, SDANN, RMSSD, TO, TS) measured by 24-hour ambulatory ECG at 6 monthssurrogate

Hypothyroidism is associated with impaired cardiac autonomic function (reduced HRV and HRT) that is not restored after 6 months of L-thyroxine replacement therapy.

Cite This Study

Çelik et al. (2011) studied this question.

synapsesocial.com/papers/6a064cf00924dc877016d90dhttps://doi.org/10.1111/j.1542-474x.2011.00461.x
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