Key result
Higher muscle mass links to reduced migraine risk, partially mediated by lower systemic inflammation.
Why the study?
The relationship between adipose-muscle distribution and its effect on migraine remains unclear.
Does increased muscle mass reduce migraine prevalence?
Cross-Sectional (n=10,400)
Does increased muscle mass reduce migraine prevalence?
p-value: p=0.045
Increased muscle mass is associated with a lower prevalence of migraines, an effect that may be partially mediated by reduced systemic inflammation.
Hypothesis-generating for muscle mass in migraine; prospective trials needed before clinical consideration.
Purpose: The relationship between adipose-muscle distribution and its effect on migraine remains unclear. This study examines the association between muscle mass and migraine prevalence and evaluates potential mediation by systemic inflammatory biomarkers. Methods: Using a cross-sectional design, we analyzed data from 10,400 participants in the National Health and Nutrition Examination Survey (NHANES) (1999-2004). The association between appendicular lean mass normalized to body mass index (ALM/BMI) and migraine prevalence was evaluated through weighted logistic regression and subgroup analyses. Mediation analyses were conducted to examine the potential mediating roles of inflammatory markers, including C-reactive protein (CRP), white blood cell count (WBC), and neutrophils, in the relationship between ALM/BMI and migraine prevalence. Genetic causality was investigated via two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) data. Conclusion: Increased muscle mass is associated with reduced migraine risk, partially mediated by attenuating systemic inflammation. These findings provide us with an approach of health management to prevent migraines.
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Jia et al. (2025) conducted a cross-sectional in Migraine (n=10,400). Appendicular lean mass normalized to body mass index (ALM/BMI) was evaluated on Migraine prevalence (p=0.045). Increased muscle mass (ALM/BMI) is associated with reduced migraine risk, an effect partially mediated by attenuating systemic inflammation (P=0.045).
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