Ragweed plants grown under elevated CO₂ levels produce pollen which elicit stronger allergic lung inflammation

BACKGROUND: levels, a hallmark of global climate change, have been shown to increase ragweed pollen production, but their effects on pollen allergenicity remain to be elucidated. Mixes of these metabolites elicited similar responses in DCs as compared to respective RWEs. CONCLUSION: levels elicit a stronger RWE-induced allergic response in vivo and in vitro and that RWE increased allergenicity depends on the interplay of multiple metabolites.