Key result
3D-grayscale microfluidics localizes platelet aggregation to high shear zones, potentially improving precision in thrombosis studies.
Why the study?
Do specific microfluidic design parameters (3D grayscale lithography, fibrillar collagen, heparin) improve the precision of occlusion time in shear-induced platelet aggregation assays using porcine whole blood?
Do specific microfluidic design parameters (3D grayscale lithography, fibrillar collagen, heparin) improve the precision of occlusion time in shear-induced platelet aggregation assays using porcine whole blood?
The use of 3D grayscale lithography and fibrillar collagen coatings significantly improves the precision of microfluidic shear-induced platelet aggregation assays, which may aid in developing reliable point-of-care diagnostics for atherothrombosis.
May improve microfluidic thrombosis assay precision in animals; leaves open human validation for point-of-care use.
m) of the high shear zone and not in the shear gradient regions. The selection of these factors in the design of point-of-care diagnostics and experimental SIPA assays may lead to increased precision and specificity in high shear thrombosis studies.
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Griffin et al. (2019) studied this question. 3D-grayscale microfluidics localized shear-induced platelet aggregation to the high shear zone rather than shear gradient regions, which may increase precision in high shear thrombosis studies.
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