Body Roundness Index is nonlinearly and independently associated with impaired diastolic function in middle-aged and older adults (P=0.006 for linearity).
Cross-Sectional (n=1,466)
Is Body Roundness Index associated with diastolic dysfunction in middle-aged and older adults?
Body Roundness Index, a novel adiposity measure, is independently associated with impaired diastolic function, highlighting the link between body shape metrics and early cardiac impairment.
p-value: p=0.006 for linearity
Background: Diastolic dysfunction (DD) represents an early indicator of cardiac impairment and is strongly linked to adverse cardiovascular outcomes. While obesity-related indices have been associated with DD, the role of Body Roundness Index (BRI)-a novel adiposity measure reflecting body shape-remains unclear. This study aimed to evaluate the association between BRI and diastolic function in a community-based cohort. Methods: This cross-sectional analysis included 1,466 participants from the Longitudinal Investigation of Osteoarthritis and Cardiovascular Health Status cohort. BRI was calculated using a validated formula, and DD was assessed via echocardiographic parameters. BRI's optimal cutoff was derived via 1000-iteration bootstrap ROC analysis. Multivariable regression models were used to evaluate associations, adjusting for age, sex, blood pressure, lipid profile, and cardiovascular comorbidities. Results: = 0.006 for linearity). Interaction analyses indicated BRI's effect on DD was not modulated by blood pressure and lipid profiles. Subgroup analyses indicated a consistent trend of association between BRI and DD. Conclusions: BRI is nonlinearly and independently associated with impaired diastolic function in middle-aged and older adults, with modest diagnostic performance. These findings provided evidence on the link between body shape metrics and DD.
Xie et al. (Mon,) conducted a cross-sectional in Diastolic dysfunction (n=1,466). Body Roundness Index (BRI) was evaluated on Diastolic dysfunction assessed via echocardiographic parameters (p=0.006 for linearity). Body Roundness Index is nonlinearly and independently associated with impaired diastolic function in middle-aged and older adults (P=0.006 for linearity).